A Novel Thioredoxin-Dependent Peroxiredoxin (TPx-Q) Plays an Important Role in Defense Against Oxidative Stress and Is a Possible Drug Target in Babesia microti
Identifieur interne : 000234 ( an2020/Analysis ); précédent : 000233; suivant : 000235A Novel Thioredoxin-Dependent Peroxiredoxin (TPx-Q) Plays an Important Role in Defense Against Oxidative Stress and Is a Possible Drug Target in Babesia microti
Auteurs : Houshuang Zhang ; Zhonghua Wang ; Jingwei Huang ; Jie Cao ; Yongzhi Zhou ; Jinlin ZhouSource :
- Frontiers in Veterinary Science [ 2297-1769 ] ; 2020.
Abstract
Thioredoxin peroxidases (TPxs) are ubiquitous cysteine-based peroxidases that reduce peroxides as part of antioxidant defenses and redox signaling and are essential for
Url:
DOI: 10.3389/fvets.2020.00076
PubMed: 32133382
PubMed Central: 7040034
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000583
- to stream Pmc, to step Curation: 000583
- to stream Pmc, to step Checkpoint: 000216
- to stream Ncbi, to step Merge: 000F97
- to stream Ncbi, to step Curation: 000F97
- to stream Ncbi, to step Checkpoint: 000F97
- to stream Main, to step Merge: 000234
- to stream Main, to step Curation: 000234
- to stream Main, to step Exploration: 000234
- to stream an2020, to step Extraction: 000234
Links to Exploration step
PMC:7040034Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Novel Thioredoxin-Dependent Peroxiredoxin (TPx-Q) Plays an Important Role in Defense Against Oxidative Stress and Is a Possible Drug Target in <italic>Babesia microti</italic></title><author><name sortKey="Zhang, Houshuang" sort="Zhang, Houshuang" uniqKey="Zhang H" first="Houshuang" last="Zhang">Houshuang Zhang</name></author><author><name sortKey="Wang, Zhonghua" sort="Wang, Zhonghua" uniqKey="Wang Z" first="Zhonghua" last="Wang">Zhonghua Wang</name></author><author><name sortKey="Huang, Jingwei" sort="Huang, Jingwei" uniqKey="Huang J" first="Jingwei" last="Huang">Jingwei Huang</name></author><author><name sortKey="Cao, Jie" sort="Cao, Jie" uniqKey="Cao J" first="Jie" last="Cao">Jie Cao</name></author><author><name sortKey="Zhou, Yongzhi" sort="Zhou, Yongzhi" uniqKey="Zhou Y" first="Yongzhi" last="Zhou">Yongzhi Zhou</name></author><author><name sortKey="Zhou, Jinlin" sort="Zhou, Jinlin" uniqKey="Zhou J" first="Jinlin" last="Zhou">Jinlin Zhou</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32133382</idno><idno type="pmc">7040034</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040034</idno><idno type="RBID">PMC:7040034</idno><idno type="doi">10.3389/fvets.2020.00076</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000583</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000583</idno><idno type="wicri:Area/Pmc/Curation">000583</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000583</idno><idno type="wicri:Area/Pmc/Checkpoint">000216</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000216</idno><idno type="wicri:Area/Ncbi/Merge">000F97</idno><idno type="wicri:Area/Ncbi/Curation">000F97</idno><idno type="wicri:Area/Ncbi/Checkpoint">000F97</idno><idno type="wicri:Area/Main/Merge">000234</idno><idno type="wicri:Area/Main/Curation">000234</idno><idno type="wicri:Area/Main/Exploration">000234</idno><idno type="wicri:Area/an2020/Extraction">000234</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Novel Thioredoxin-Dependent Peroxiredoxin (TPx-Q) Plays an Important Role in Defense Against Oxidative Stress and Is a Possible Drug Target in <italic>Babesia microti</italic></title><author><name sortKey="Zhang, Houshuang" sort="Zhang, Houshuang" uniqKey="Zhang H" first="Houshuang" last="Zhang">Houshuang Zhang</name></author><author><name sortKey="Wang, Zhonghua" sort="Wang, Zhonghua" uniqKey="Wang Z" first="Zhonghua" last="Wang">Zhonghua Wang</name></author><author><name sortKey="Huang, Jingwei" sort="Huang, Jingwei" uniqKey="Huang J" first="Jingwei" last="Huang">Jingwei Huang</name></author><author><name sortKey="Cao, Jie" sort="Cao, Jie" uniqKey="Cao J" first="Jie" last="Cao">Jie Cao</name></author><author><name sortKey="Zhou, Yongzhi" sort="Zhou, Yongzhi" uniqKey="Zhou Y" first="Yongzhi" last="Zhou">Yongzhi Zhou</name></author><author><name sortKey="Zhou, Jinlin" sort="Zhou, Jinlin" uniqKey="Zhou J" first="Jinlin" last="Zhou">Jinlin Zhou</name></author></analytic><series><title level="j">Frontiers in Veterinary Science</title><idno type="eISSN">2297-1769</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Thioredoxin peroxidases (TPxs) are ubiquitous cysteine-based peroxidases that reduce peroxides as part of antioxidant defenses and redox signaling and are essential for <italic>Babesia microti</italic> protection against adverse environment agents like reactive oxygen species (ROS) and reactive nitrogen species (RNS). To better systematically understand TPxs, we identified a novel 2-Cys peroxiredoxin-Q (BmTPx-Q) of <italic>B. microti</italic>. The full-length BmTPx-Q gene is 653 bp that consists of an intact open reading frame of 594 bp that encodes a 197-amino acid protein. The predicted protein has a molecular weight of 22.3 kDa and an isoelectric point of 9.18. Moreover, BmTPx-Q showed low identity at the amino acid level to other peroxiredoxins (Prxs) among the currently known subfamilies. The recombinant BmTPx-Q protein (rBmTPx-Q) was expressed in <italic>Escherichia coli</italic> and purified with beads. The native protein BmTPx-Q was detected using mouse anti-BmTPx-Q polyclonal serum with western blotting and indirect immunofluorescence assay (IFA). In addition, enzyme activity was observed using nicotinamide adenine dinucleotide phosphate (NADPH) as substrate and triggered the NADPH-dependent reduction of the Trx/TrxR system. It was also discovered that BmTPx-Q mainly exists as a monomer whether under its native or functional states. In addition, when incubated with Chloroquine diphosphate salt for 24 h <italic>in vitro</italic>, the expression of BmTPx-Q showed a marked downward trend with the increase of drug concentration. These results suggest that <italic>B. microti</italic> uses BmTPx-Q to reduce and detoxify hydrogen peroxides to survive and proliferate inside the host. Furthermore, BmTPx-Q showed the lowest identity with host enzymes and could be a potential drug target for the development of novel strategies to control <italic>B. microti</italic> infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Herwaldt, Bl" uniqKey="Herwaldt B">BL Herwaldt</name></author><author><name sortKey="Caccio, S" uniqKey="Caccio S">S Caccio</name></author><author><name sortKey="Gherlinzoni, F" uniqKey="Gherlinzoni F">F Gherlinzoni</name></author><author><name sortKey="Aspock, H" uniqKey="Aspock H">H Aspöck</name></author><author><name sortKey="Slemenda, Sb" uniqKey="Slemenda S">SB Slemenda</name></author><author><name sortKey="Piccaluga, P" uniqKey="Piccaluga P">P Piccaluga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Obiegala, A" uniqKey="Obiegala A">A Obiegala</name></author><author><name sortKey="Pfeffer, M" uniqKey="Pfeffer M">M Pfeffer</name></author><author><name sortKey="Pfister, K" uniqKey="Pfister K">K Pfister</name></author><author><name sortKey="Karnath, C" uniqKey="Karnath C">C Karnath</name></author><author><name sortKey="Silaghi, C" uniqKey="Silaghi C">C Silaghi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vannier, E" uniqKey="Vannier E">E Vannier</name></author><author><name sortKey="Krause, Pj" uniqKey="Krause P">PJ Krause</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Homer, Mj" uniqKey="Homer M">MJ Homer</name></author><author><name sortKey="Aguilar Delfin, I" uniqKey="Aguilar Delfin I">I Aguilar-Delfin</name></author><author><name sortKey="Telford, Sr" uniqKey="Telford S">SR Telford</name></author><author><name sortKey="Krause, Pj" uniqKey="Krause P">PJ Krause</name></author><author><name sortKey="Persing, Dh" uniqKey="Persing D">DH Persing</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vial, Hj" uniqKey="Vial H">HJ Vial</name></author><author><name sortKey="Gorenflot, A" uniqKey="Gorenflot A">A Gorenflot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gray, J" uniqKey="Gray J">J Gray</name></author><author><name sortKey="Zintl, A" uniqKey="Zintl A">A Zintl</name></author><author><name sortKey="Hildebrandt, A" uniqKey="Hildebrandt A">A Hildebrandt</name></author><author><name sortKey="Hunfeld, Kp" uniqKey="Hunfeld K">KP Hunfeld</name></author><author><name sortKey="Weiss, L" uniqKey="Weiss L">L Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Robinson, Mw" uniqKey="Robinson M">MW Robinson</name></author><author><name sortKey="Hutchinson, At" uniqKey="Hutchinson A">AT Hutchinson</name></author><author><name sortKey="Dalton, Jp" uniqKey="Dalton J">JP Dalton</name></author><author><name sortKey="Donnelly, S" uniqKey="Donnelly S">S Donnelly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reuter, S" uniqKey="Reuter S">S Reuter</name></author><author><name sortKey="Gupta, Sc" uniqKey="Gupta S">SC Gupta</name></author><author><name sortKey="Chaturvedi, Mm" uniqKey="Chaturvedi M">MM Chaturvedi</name></author><author><name sortKey="Aggarwal, Bb" uniqKey="Aggarwal B">BB Aggarwal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kawazu, S" uniqKey="Kawazu S">S Kawazu</name></author><author><name sortKey="Komaki Yasuda, K" uniqKey="Komaki Yasuda K">K Komaki-Yasuda</name></author><author><name sortKey="Oku, H" uniqKey="Oku H">H Oku</name></author><author><name sortKey="Kano, S" uniqKey="Kano S">S Kano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bosch, Ss" uniqKey="Bosch S">SS Bosch</name></author><author><name sortKey="Kronenberger, T" uniqKey="Kronenberger T">T Kronenberger</name></author><author><name sortKey="Meissner, Ka" uniqKey="Meissner K">KA Meissner</name></author><author><name sortKey="Zimbres, Fm" uniqKey="Zimbres F">FM Zimbres</name></author><author><name sortKey="Stegehake, D" uniqKey="Stegehake D">D Stegehake</name></author><author><name sortKey="Izui, Nm" uniqKey="Izui N">NM Izui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poole, Lb" uniqKey="Poole L">LB Poole</name></author><author><name sortKey="Hall, A" uniqKey="Hall A">A Hall</name></author><author><name sortKey="Nelson, Kj" uniqKey="Nelson K">KJ Nelson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fujii, J" uniqKey="Fujii J">J Fujii</name></author><author><name sortKey="Ikeda, Y" uniqKey="Ikeda Y">Y Ikeda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nickel, C" uniqKey="Nickel C">C Nickel</name></author><author><name sortKey="Trujillo, M" uniqKey="Trujillo M">M Trujillo</name></author><author><name sortKey="Rahlfs, S" uniqKey="Rahlfs S">S Rahlfs</name></author><author><name sortKey="Deponte, M" uniqKey="Deponte M">M Deponte</name></author><author><name sortKey="Radi, R" uniqKey="Radi R">R Radi</name></author><author><name sortKey="Becker, K" uniqKey="Becker K">K Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nelson, Kj" uniqKey="Nelson K">KJ Nelson</name></author><author><name sortKey="Knutson, St" uniqKey="Knutson S">ST Knutson</name></author><author><name sortKey="Soito, L" uniqKey="Soito L">L Soito</name></author><author><name sortKey="Klomsiri, C" uniqKey="Klomsiri C">C Klomsiri</name></author><author><name sortKey="Poole, Lb" uniqKey="Poole L">LB Poole</name></author><author><name sortKey="Fetrow, Js" uniqKey="Fetrow J">JS Fetrow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chae, Hz" uniqKey="Chae H">HZ Chae</name></author><author><name sortKey="Robison, K" uniqKey="Robison K">K Robison</name></author><author><name sortKey="Poole, Lb" uniqKey="Poole L">LB Poole</name></author><author><name sortKey="Church, G" uniqKey="Church G">G Church</name></author><author><name sortKey="Storz, G" uniqKey="Storz G">G Storz</name></author><author><name sortKey="Rhee, Sg" uniqKey="Rhee S">SG Rhee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karplus, Pa" uniqKey="Karplus P">PA Karplus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perkins, A" uniqKey="Perkins A">A Perkins</name></author><author><name sortKey="Nelson, Kj" uniqKey="Nelson K">KJ Nelson</name></author><author><name sortKey="Parsonage, D" uniqKey="Parsonage D">D Parsonage</name></author><author><name sortKey="Poole, Lb" uniqKey="Poole L">LB Poole</name></author><author><name sortKey="Karplus, Pa" uniqKey="Karplus P">PA Karplus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hall, A" uniqKey="Hall A">A Hall</name></author><author><name sortKey="Karplus, Pa" uniqKey="Karplus P">PA Karplus</name></author><author><name sortKey="Poole, Lb" uniqKey="Poole L">LB Poole</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krnajski, Z" uniqKey="Krnajski Z">Z Krnajski</name></author><author><name sortKey="Gilberger, Tw" uniqKey="Gilberger T">TW Gilberger</name></author><author><name sortKey="Walter, Rd" uniqKey="Walter R">RD Walter</name></author><author><name sortKey="Cowman, Af" uniqKey="Cowman A">AF Cowman</name></author><author><name sortKey="Muller, S" uniqKey="Muller S">S Müller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sarma, Gn" uniqKey="Sarma G">GN Sarma</name></author><author><name sortKey="Nickel, C" uniqKey="Nickel C">C Nickel</name></author><author><name sortKey="Rahlfs, S" uniqKey="Rahlfs S">S Rahlfs</name></author><author><name sortKey="Fischer, M" uniqKey="Fischer M">M Fischer</name></author><author><name sortKey="Becker, K" uniqKey="Becker K">K Becker</name></author><author><name sortKey="Karplus, Pa" uniqKey="Karplus P">PA Karplus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hakimi, H" uniqKey="Hakimi H">H Hakimi</name></author><author><name sortKey="Asada, M" uniqKey="Asada M">M Asada</name></author><author><name sortKey="Angeles, Jm" uniqKey="Angeles J">JM Angeles</name></author><author><name sortKey="Inoue, N" uniqKey="Inoue N">N Inoue</name></author><author><name sortKey="Kawazu, S" uniqKey="Kawazu S">S Kawazu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hakimi, H" uniqKey="Hakimi H">H Hakimi</name></author><author><name sortKey="Suganuma, K" uniqKey="Suganuma K">K Suganuma</name></author><author><name sortKey="Usui, M" uniqKey="Usui M">M Usui</name></author><author><name sortKey="Masuda Suganuma, H" uniqKey="Masuda Suganuma H">H Masuda-Suganuma</name></author><author><name sortKey="Angeles, Jm" uniqKey="Angeles J">JM Angeles</name></author><author><name sortKey="Asada, M" uniqKey="Asada M">M Asada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hakimi, H" uniqKey="Hakimi H">H Hakimi</name></author><author><name sortKey="Goto, Y" uniqKey="Goto Y">Y Goto</name></author><author><name sortKey="Suganuma, K" uniqKey="Suganuma K">K Suganuma</name></author><author><name sortKey="Angeles, Jm" uniqKey="Angeles J">JM Angeles</name></author><author><name sortKey="Kawai, S" uniqKey="Kawai S">S Kawai</name></author><author><name sortKey="Inoue, N" uniqKey="Inoue N">N Inoue</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Usui, M" uniqKey="Usui M">M Usui</name></author><author><name sortKey="Masuda Suganuma, H" uniqKey="Masuda Suganuma H">H Masuda-Suganuma</name></author><author><name sortKey="Fukumoto, S" uniqKey="Fukumoto S">S Fukumoto</name></author><author><name sortKey="Angeles, Jm" uniqKey="Angeles J">JM Angeles</name></author><author><name sortKey="Hakimi, H" uniqKey="Hakimi H">H Hakimi</name></author><author><name sortKey="Inoue, N" uniqKey="Inoue N">N Inoue</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Knoops, B" uniqKey="Knoops B">B Knoops</name></author><author><name sortKey="Argyropoulou, V" uniqKey="Argyropoulou V">V Argyropoulou</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S Becker</name></author><author><name sortKey="Ferte, L" uniqKey="Ferte L">L Ferté</name></author><author><name sortKey="Kuznetsova, O" uniqKey="Kuznetsova O">O Kuznetsova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hampton, Mb" uniqKey="Hampton M">MB Hampton</name></author><author><name sortKey="O Connor, Km" uniqKey="O Connor K">KM O'Connor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perkins, A" uniqKey="Perkins A">A Perkins</name></author><author><name sortKey="Gretes, Mc" uniqKey="Gretes M">MC Gretes</name></author><author><name sortKey="Nelson, Kj" uniqKey="Nelson K">KJ Nelson</name></author><author><name sortKey="Poole, Lb" uniqKey="Poole L">LB Poole</name></author><author><name sortKey="Karplus, Pa" uniqKey="Karplus P">PA Karplus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buchko, Gw" uniqKey="Buchko G">GW Buchko</name></author><author><name sortKey="Perkins, A" uniqKey="Perkins A">A Perkins</name></author><author><name sortKey="Parsonage, D" uniqKey="Parsonage D">D Parsonage</name></author><author><name sortKey="Poole, Lb" uniqKey="Poole L">LB Poole</name></author><author><name sortKey="Karplus, Pa" uniqKey="Karplus P">PA Karplus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Masatani, T" uniqKey="Masatani T">T Masatani</name></author><author><name sortKey="Asada, M" uniqKey="Asada M">M Asada</name></author><author><name sortKey="Ichikawa Seki, M" uniqKey="Ichikawa Seki M">M Ichikawa-Seki</name></author><author><name sortKey="Usui, M" uniqKey="Usui M">M Usui</name></author><author><name sortKey="Terkawi, Ma" uniqKey="Terkawi M">MA Terkawi</name></author><author><name sortKey="Hayashi, K" uniqKey="Hayashi K">K Hayashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Su, T" uniqKey="Su T">T Su</name></author><author><name sortKey="Si, M" uniqKey="Si M">M Si</name></author><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author><author><name sortKey="Yao, S" uniqKey="Yao S">S Yao</name></author><author><name sortKey="Che, C" uniqKey="Che C">C Che</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tailor, V" uniqKey="Tailor V">V Tailor</name></author><author><name sortKey="Ballal, A" uniqKey="Ballal A">A Ballal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kong, W" uniqKey="Kong W">W Kong</name></author><author><name sortKey="Shiota, S" uniqKey="Shiota S">S Shiota</name></author><author><name sortKey="Shi, Y" uniqKey="Shi Y">Y Shi</name></author><author><name sortKey="Nakayama, H" uniqKey="Nakayama H">H Nakayama</name></author><author><name sortKey="Nakayama, K" uniqKey="Nakayama K">K Nakayama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reyes, Am" uniqKey="Reyes A">AM Reyes</name></author><author><name sortKey="Vazquez, Ds" uniqKey="Vazquez D">DS Vazquez</name></author><author><name sortKey="Zeida, A" uniqKey="Zeida A">A Zeida</name></author><author><name sortKey="Hugo, M" uniqKey="Hugo M">M Hugo</name></author><author><name sortKey="Pi Eyro, Md" uniqKey="Pi Eyro M">MD Piñeyro</name></author><author><name sortKey="De Armas, Mi" uniqKey="De Armas M">MI De Armas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rhee, Sg" uniqKey="Rhee S">SG Rhee</name></author><author><name sortKey="Kil, Is" uniqKey="Kil I">IS Kil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cornillot, E" uniqKey="Cornillot E">E Cornillot</name></author><author><name sortKey="Kaddour, Kh" uniqKey="Kaddour K">KH Kaddour</name></author><author><name sortKey="Dassouli, A" uniqKey="Dassouli A">A Dassouli</name></author><author><name sortKey="Noel, B" uniqKey="Noel B">B Noel</name></author><author><name sortKey="Ranwez, V" uniqKey="Ranwez V">V Ranwez</name></author><author><name sortKey="Vacherie, B" uniqKey="Vacherie B">B Vacherie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name></author><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name></author><author><name sortKey="Gong, H" uniqKey="Gong H">H Gong</name></author><author><name sortKey="Cao, J" uniqKey="Cao J">J Cao</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hai, X" uniqKey="Hai X">X Hai</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name></author><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name></author><author><name sortKey="Gong, H" uniqKey="Gong H">H Gong</name></author><author><name sortKey="Cao, J" uniqKey="Cao J">J Cao</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sauri, H" uniqKey="Sauri H">H Sauri</name></author><author><name sortKey="Butterfield, L" uniqKey="Butterfield L">L Butterfield</name></author><author><name sortKey="Kim, A" uniqKey="Kim A">A Kim</name></author><author><name sortKey="Shau, H" uniqKey="Shau H">H Shau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thurman, Rg" uniqKey="Thurman R">RG Thurman</name></author><author><name sortKey="Ley, Hg" uniqKey="Ley H">HG Ley</name></author><author><name sortKey="Scholz, R" uniqKey="Scholz R">R Scholz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, Sw" uniqKey="Kang S">SW Kang</name></author><author><name sortKey="Baines, I" uniqKey="Baines I">I Baines</name></author><author><name sortKey="Rhee, Sg" uniqKey="Rhee S">SG Rhee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, J" uniqKey="Huang J">J Huang</name></author><author><name sortKey="Xiong, K" uniqKey="Xiong K">K Xiong</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name></author><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name></author><author><name sortKey="Cao, J" uniqKey="Cao J">J Cao</name></author><author><name sortKey="Gong, H" uniqKey="Gong H">H Gong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, J" uniqKey="Huang J">J Huang</name></author><author><name sortKey="Xiong, K" uniqKey="Xiong K">K Xiong</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name></author><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name></author><author><name sortKey="Cao, J" uniqKey="Cao J">J Cao</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pfaffl, Mw" uniqKey="Pfaffl M">MW Pfaffl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blasa, M" uniqKey="Blasa M">M Blasa</name></author><author><name sortKey="Angelino, D" uniqKey="Angelino D">D Angelino</name></author><author><name sortKey="Gennari, L" uniqKey="Gennari L">L Gennari</name></author><author><name sortKey="Ninfali, P" uniqKey="Ninfali P">P Ninfali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fredriksson, K" uniqKey="Fredriksson K">K Fredriksson</name></author><author><name sortKey="Stridh, H" uniqKey="Stridh H">H Stridh</name></author><author><name sortKey="Lundahl, J" uniqKey="Lundahl J">J Lundahl</name></author><author><name sortKey="Rennard, Si" uniqKey="Rennard S">SI Rennard</name></author><author><name sortKey="Skold, Cm" uniqKey="Skold C">CM Skold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brehelin, C" uniqKey="Brehelin C">C Bréhélin</name></author><author><name sortKey="Meyer, Eh" uniqKey="Meyer E">EH Meyer</name></author><author><name sortKey="De Souris, Jp" uniqKey="De Souris J">JP de Souris</name></author><author><name sortKey="Bonnard, G" uniqKey="Bonnard G">G Bonnard</name></author><author><name sortKey="Meyer, Y" uniqKey="Meyer Y">Y Meyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rouhier, N" uniqKey="Rouhier N">N Rouhier</name></author><author><name sortKey="Jacquot, Jp" uniqKey="Jacquot J">JP Jacquot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Banerjee, M" uniqKey="Banerjee M">M Banerjee</name></author><author><name sortKey="Chakravarty, D" uniqKey="Chakravarty D">D Chakravarty</name></author><author><name sortKey="Ballal, A" uniqKey="Ballal A">A Ballal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Em" uniqKey="Lee E">EM Lee</name></author><author><name sortKey="Lee, Ss" uniqKey="Lee S">SS Lee</name></author><author><name sortKey="Tripathi, Bn" uniqKey="Tripathi B">BN Tripathi</name></author><author><name sortKey="Jung, Hs" uniqKey="Jung H">HS Jung</name></author><author><name sortKey="Cao, Gp" uniqKey="Cao G">GP Cao</name></author><author><name sortKey="Lee, Y" uniqKey="Lee Y">Y Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clarke, Dj" uniqKey="Clarke D">DJ Clarke</name></author><author><name sortKey="Ortega, Xp" uniqKey="Ortega X">XP Ortega</name></author><author><name sortKey="Mackay, Cl" uniqKey="Mackay C">CL Mackay</name></author><author><name sortKey="Valvano, Ma" uniqKey="Valvano M">MA Valvano</name></author><author><name sortKey="Govan, Jr" uniqKey="Govan J">JR Govan</name></author><author><name sortKey="Campopiano, Dj" uniqKey="Campopiano D">DJ Campopiano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rhee, Sg" uniqKey="Rhee S">SG Rhee</name></author><author><name sortKey="Woo, Ha" uniqKey="Woo H">HA Woo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dietz, Kj" uniqKey="Dietz K">KJ Dietz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okazaki, S" uniqKey="Okazaki S">S Okazaki</name></author><author><name sortKey="Naganuma, A" uniqKey="Naganuma A">A Naganuma</name></author><author><name sortKey="Kuge, S" uniqKey="Kuge S">S Kuge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Horling, F" uniqKey="Horling F">F Horling</name></author><author><name sortKey="Lamkemeyer, P" uniqKey="Lamkemeyer P">P Lamkemeyer</name></author><author><name sortKey="Konig, J" uniqKey="Konig J">J König</name></author><author><name sortKey="Finkemeier, I" uniqKey="Finkemeier I">I Finkemeier</name></author><author><name sortKey="Kandlbinder, A" uniqKey="Kandlbinder A">A Kandlbinder</name></author><author><name sortKey="Baier, M" uniqKey="Baier M">M Baier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chae, Hz" uniqKey="Chae H">HZ Chae</name></author><author><name sortKey="Uhm, Tb" uniqKey="Uhm T">TB Uhm</name></author><author><name sortKey="Rhee, Sg" uniqKey="Rhee S">SG Rhee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Konig, J" uniqKey="Konig J">J König</name></author><author><name sortKey="Galliardt, H" uniqKey="Galliardt H">H Galliardt</name></author><author><name sortKey="Jutte, P" uniqKey="Jutte P">P Jütte</name></author><author><name sortKey="Sch Per, S" uniqKey="Sch Per S">S Schäper</name></author><author><name sortKey="Dittmann, L" uniqKey="Dittmann L">L Dittmann</name></author><author><name sortKey="Dietz, Kj" uniqKey="Dietz K">KJ Dietz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Ye" uniqKey="Kim Y">YE Kim</name></author><author><name sortKey="Hipp, Ms" uniqKey="Hipp M">MS Hipp</name></author><author><name sortKey="Bracher, A" uniqKey="Bracher A">A Bracher</name></author><author><name sortKey="Hayer Hartl, M" uniqKey="Hayer Hartl M">M Hayer-Hartl</name></author><author><name sortKey="Hartl, Fu" uniqKey="Hartl F">FU Hartl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cho, C" uniqKey="Cho C">C Cho</name></author><author><name sortKey="Lee, Gw" uniqKey="Lee G">GW Lee</name></author><author><name sortKey="Hong, Sh" uniqKey="Hong S">SH Hong</name></author><author><name sortKey="Kaur, S" uniqKey="Kaur S">S Kaur</name></author><author><name sortKey="Jung, Kw" uniqKey="Jung K">KW Jung</name></author><author><name sortKey="Jung, Jh" uniqKey="Jung J">JH Jung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koncarevic, S" uniqKey="Koncarevic S">S Koncarevic</name></author><author><name sortKey="Rohrbach, P" uniqKey="Rohrbach P">P Rohrbach</name></author><author><name sortKey="Deponte, M" uniqKey="Deponte M">M Deponte</name></author><author><name sortKey="Krohne, G" uniqKey="Krohne G">G Krohne</name></author><author><name sortKey="Prieto, Jh" uniqKey="Prieto J">JH Prieto</name></author><author><name sortKey="Yates, J" uniqKey="Yates J">J Yates</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mendes, Re" uniqKey="Mendes R">RE Mendes</name></author><author><name sortKey="Perez Ecija, Ra" uniqKey="Perez Ecija R">RA Pérez-Ecija</name></author><author><name sortKey="Zafra, R" uniqKey="Zafra R">R Zafra</name></author><author><name sortKey="Buffoni, L" uniqKey="Buffoni L">L Buffoni</name></author><author><name sortKey="Martinez Moreno, A" uniqKey="Martinez Moreno A">A Martínez-Moreno</name></author><author><name sortKey="Dalton, Jp" uniqKey="Dalton J">JP Dalton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yano, K" uniqKey="Yano K">K Yano</name></author><author><name sortKey="Komaki Yasuda, K" uniqKey="Komaki Yasuda K">K Komaki-Yasuda</name></author><author><name sortKey="Kobayashi, T" uniqKey="Kobayashi T">T Kobayashi</name></author><author><name sortKey="Takemae, H" uniqKey="Takemae H">H Takemae</name></author><author><name sortKey="Kita, K" uniqKey="Kita K">K Kita</name></author><author><name sortKey="Kano, S" uniqKey="Kano S">S Kano</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Cao, Jie" sort="Cao, Jie" uniqKey="Cao J" first="Jie" last="Cao">Jie Cao</name><name sortKey="Huang, Jingwei" sort="Huang, Jingwei" uniqKey="Huang J" first="Jingwei" last="Huang">Jingwei Huang</name><name sortKey="Wang, Zhonghua" sort="Wang, Zhonghua" uniqKey="Wang Z" first="Zhonghua" last="Wang">Zhonghua Wang</name><name sortKey="Zhang, Houshuang" sort="Zhang, Houshuang" uniqKey="Zhang H" first="Houshuang" last="Zhang">Houshuang Zhang</name><name sortKey="Zhou, Jinlin" sort="Zhou, Jinlin" uniqKey="Zhou J" first="Jinlin" last="Zhou">Jinlin Zhou</name><name sortKey="Zhou, Yongzhi" sort="Zhou, Yongzhi" uniqKey="Zhou Y" first="Yongzhi" last="Zhou">Yongzhi Zhou</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/an2020/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000234 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/an2020/Analysis/biblio.hfd -nk 000234 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= an2020
|étape= Analysis
|type= RBID
|clé= PMC:7040034
|texte= A Novel Thioredoxin-Dependent Peroxiredoxin (TPx-Q) Plays an Important Role in Defense Against Oxidative Stress and Is a Possible Drug Target in Babesia microti
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/an2020/Analysis/RBID.i -Sk "pubmed:32133382" \
| HfdSelect -Kh $EXPLOR_AREA/Data/an2020/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |